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The UC Berkeley Center for the Science of Psychedelics BCSP Remarkably, R-DOI at doses as low as 0.01 mg/kg administered nose-only prior to OVA administration prevented the symptoms of allergic asthma from developing, including inflammation and eosinophilia. In mechanistic studies, cells of the lung were further analyzed by both gene expression and flow cytometry. Some, but not all, proinflammatory cytokines were found to be repressed in the R-DOI pretreated animals. For example, expression of IL-4, a proinflammatory cytokine implicated in asthma was unaffected by R-DOI, whereas expression levels of others including IL-5, IL-13, and granulocyte-macrophage colony-stimulating factor were all significantly reduced. These results suggested that unlike conventional anti-inflammatory treatments like steroids, which simply repress the immune system, R-DOI selectively targets only certain key components relevant to the pathology. During the very early years, when LSD was considered to be so